James C. Brust, MD

Dr. Brust is a Professor of Medicine, with joint appointments in the Divisions of General Internal Medicine and Infectious Diseases. He graduated from the College of Physicians & Surgeons at Columbia University and completed both a residency in Internal Medicine and a fellowship in Infectious Diseases at the Columbia University Medical Center.

Dr. Brust's research is focused on the dual epidemics of multidrug-resistant tuberculosis (MDR TB) and HIV in South Africa. With multiple US and international collaborators, his multidisciplinary research group is studying treatment outcomes of MDR TB/HIV co-infected patients, transmission patterns of drug-resistant TB, pharmacology of new and repurposed TB medications, and genetic mechanisms of drug-resistance. He has funding from NIAID to examine the emergence of resistance to the new TB medication bedaquiline in patients with MDR and XDR TB. He is also the PI of a randomized clinical trial to determine if therapeutic drug monitoring for linezolid can prevent toxicity and premature discontinuation in patients with rifampin-resistant TB in South Africa.

Dr. Brust is a practicing infectious diseases subspecialist and maintains an active patient panel in the Montefiore Center for Positive Living/Infectious Diseases Clinic. He currently serves on multiple state and national guidelines committees related to the management of HIV and tuberculosis.