James C. Brust, MD

Dr. Brust is a Professor of Medicine, with joint appointments in the Divisions of General Internal Medicine and Infectious Diseases. He graduated from the College of Physicians & Surgeons at Columbia University and completed both a residency in Internal Medicine and a fellowship in Infectious Diseases at the Columbia University Medical Center. 

Dr. Brust's research is focused on the dual epidemics of multidrug-resistant tuberculosis (MDR TB) and HIV in South Africa. With multiple US and international collaborators, his multidisciplinary research group is studying treatment outcomes of MDR TB/HIV co-infected patients, transmission patterns of drug-resistant TB, pharmacology of new and repurposed TB medications, and genetic mechanisms of drug-resistance. He has funding from NIAID to examinine the emergence of resistance to the new TB medication bedaquiline in patients with MDR and XDR TB.